Abstract
Ronstar was applied at concentration s of 2.0,5.75 and 9.5 mg/L. Histological alterations were determined in liver and kidney of the catfish Clarias lazera. The histological changes in liver of catfish C lazera intoxicated with different doses of Ronstar, included dilation of the blood veins and sinusoids, vacuolation in the cytoplasm and pyknosis in the nuclei of the hepatocytes, haemorrhage is also noticed in the veins and sinusoids. The phagocytic Kupffer and endothelial cells are also abundant as an immunoresponse reaction. The vacuolation is the most frequent histological alteration observed at all tested doses of Ronstar. Ascorbic acid (lOmg/lkg of body *weight)was reported to reduce some of the histological damage occurred in the liver tissue. It alleviated the rate ofpyknosisand vacuolationThe rate of ascorbic acid healing effect depends on the Ronstar tested dose. Ronstar induced different histological alterations in the kidney of the catfish C lazera The glomeruli became expanded and their capillaries were extended, the subcapsular space enlarged or disappeared. The haemopoietic tissue exhibited some vaculation and the renal tubules were swollen or degenerated. Some of them took an irregular shape .The expanded glomeruli with extended capillaries
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