Abstract
7-Difluoromethylylgenistein (FMG), prepared by the difluoromethylation and alkylation of genistein, is an active new chemical entity. The protective effect of FMG on PC12 cell injury by oxidative stress was studied, and its molecular mechanism of action was also investigated. This paper demonstrated that pretreatment with FMG could improve cell growth and proliferation in a concentration dependent manner, reduce the release of lactate dehydrogenase (LDH), suppresses the H2O2-induced apoptosis of PC12 cells, up-regulate expression of phosphorylated ERK1/2 and suppress activation of p38 in H2O2-induced PC12 cells. Therefore, these results suggested that FMG possessed the protective activity of PC12 cells injury by H2O2 in vitro. The protective activity is associated with up-regulating the expression of phosphorylation ERK1/2 and suppressing the activation of p38. Key words: Genistein, 7- difluoromethylylgenistein, PC12 cell, oxidative stress, protective effect.
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