Abstract
Background: Carissa edulis is generally used for the treatment of diverse ailments, but little or no interest has been shown on its hepatoprotective properties. This research work was aimed at evaluating the safety and claimed hepatoprotective activity of Carissa edulis.Method: For the intent of data collection, the method of Li et al., 2011 was used. In this method animals were treated with (250,500 and 1000mg/kg) of stem bark extract. The extract was given daily by gavage to the animals for 28 consecutive days. The 50% v/vCCl4 and olive oil was gavaged through gastric tube twice a week. The tests conducted were liver function test, liver antioxidant enzymes test, lipid profile test as well as Histopathological assessment of the liver sections.Results: Results of the study revealed that the markers in the animal treated with CCl4 were significantly higher than the normal control at (P<0.05). While blood samples from animals treated with the stem bark extracts were significantly lower than the CCl4 group at (P<0.05).Conclusion: These results imply that the ethanolic stem bark extract of Carissa edulis have a protective effect against CCl4 induced hepato - cellular injury.  Â
Highlights
The liver plays a vital role in transforming and clearing chemicals and is at risk of toxicity from these agents
It has been established that different inflammatory cytokines such as tumor necrosis factors (TNF) - interferon (IFN)-y, and interleukin (IL) B formed during liver injury are implicated in promoting tissue damage (Ishida et al, 2002)
The clinical presentation of HILI matches those of Druginduced liver injury (DILI) (Pantano et al, 2016)
Summary
The liver plays a vital role in transforming and clearing chemicals and is at risk of toxicity from these agents. Conclusion: These results imply that the ethanolic stem bark extract of Carissa edulis have a protective effect against CCl4 induced hepato - cellular injury. In addition HILI and DILI share common characteristics, as both cases are caused by chemical components that are formed either by natural or synthetic processes. These natural and synthetic chemicals are foreign to the body and have need of metabolic breakdown to eliminate. The extract in addition scavenged DPPH (Diphenylpicryihydrazyl) and prevented lipid per oxidation in rat’s brain homogenate These results suggest that the alcoholic extract of Carissa edulis possibly exert in vivo inflammatory and antioxidant properties which may contribute to its activity. The needs for a hepatoprotective study of this plant to ascertain its effect on the liver because the treatment and management of this organ results in more economic problems
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Pharmacology and Toxicology
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
