Abstract
A316 Objective: To investivate the protection effects of N-acetyleysteine on the hepatic injury of brain-dead rats. Methods: 30 rats were randomly divided into 3 groups: Control group (C), brain death group (B), and N-acetyleysteine pretreatment group (N). 4 hour after the establishment of the brain death model, the sera were collected and the levels of ALT, AST, TNF-α, and HA were determined. And the hepatic tissue were excised for the electromicroscopic examination. Results: At 4h, the levels of of ALT, AST, TNF-α, and HA in the group N were significantly higer than those in the group C, but these factors were significantly lower than group B. Under electromicroscopy:Kupffer cells were activated, sinusoidal endothelial cells(SEC) denuded, fenestration widened in group B, but in group N, the activation of Kupffer cells were obviously liminated, and The SEC were almost intact. Conclution: Brain death could cause hepatic damage and N-acetyleysteine could protect liver from injury to brain-death rats.
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