Abstract
Molecular and biological features of triple negative breast cancer (TN BC) determine the limited possibilities of systemic therapy and, as a consequence, the more aggressive course of the disease. Taxanes are one of the most effective chemotherapies used in breast cancer therapy. The special form of paclitaxel nab-paclitaxel makes it possible to obtain an objective and a subjective effect, which is especially important in the pre-treated patients. In addition, the drug has a favourable safety profile and a well-controlled toxicity.The article contains a review of the literature on the prospects for the use of nab-paclitaxel in breast cancer, especially in its triple negative version, and a description of the clinical case of therapy with a combination of cisplatin and nab-paclitaxel in a young patient with BRCA-1-associated TN breastcancer.
Highlights
Молекулярно-биологические особенности трижды негативного рака молочной железы (ТН Рак молочной железы (РМЖ)) определяют ограниченные возможности системной терапии и, как следствие, более агрессивное течение болезни
Taxanes are one of the most effective chemotherapies used in breast cancer therapy
The special form of paclitaxel - nab-paclitaxel - makes it possible to obtain an objective and a subjective effect, which is especially important in the pre-treated patients
Summary
СУСЛОВА3 1 ГБУЗ «Московский клинический научный центр им. Москвы 2 ФГБУ «Национальный медицинский исследовательский центр онкологии им. Блохина» Минздрава России, Москва 3 ГБУЗ «Онкологический диспансер No4 Департамента здравоохранения г.
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