THE PROSPECTIVE STUDY OF COAGULATION PROFILE IN CHRONIC LIVER DISEASES AT TERTIARY CARE CENTRE.

Abstract

Background:- The liver is the body's largest and a vital organ and plays a major role in haemostasis, as most of the coagulation factors, anticoagulant proteins and components of the brinolysis system are synthesized here. Balance between these procoagulant and anticoagulant processes is essential to prevent unwanted thrombin generation under normal physiological conditions. Objectives:-To study coagulation defects in patients of chronic liver diseases and to assess the effect of chronic liver diseases on intrinsic and extrinsic pathway through various coagulation tests and its correlation with platelet count. Materials and Methods :- Total 100 cases suffering from liver cirrhosis, chronic hepatitis and hepatocellular carcinoma admitted in medical and surgical wards were studied. Venous blood was collected and coagulation tests like BT, PT, APTT, D-dimer were done. Result :- Out of 100 cases of chronic liver diseases, 58% were diagnosed as liver cirrhosis, 37% were chronic hepatitis and 4% were hepatocellular carcinoma. The commonest coagulation defect in chronic liver diseases was prolonged PT. BT,PT,APTT, D-dimer was signicantly increased and platelet count decreased in hepatocellular carcinoma and liver cirrhosis but within normal range in chronic hepatitis. Conclusion:- Laboratory tests suggest the abnormality in coagulation system which if done routinely can be helpful in better management of patients with liver diseases.