Abstract
BackgroundThe aim of this study is to evaluate the prophylactic effects of probiotic mixture BIFICO on antibiotic-induced gut dysbiosis (AIGD) and the influence on the change of the gut microbiota.MethodsWe conducted a prospective, randomized, controlled study and divided 196 patients who required intravenous beta-lactam antibiotics into three groups: a control group (no probiotics), a regular group (840 mg of BIFICO), and a double-dosage group (1680 mg of BIFICO). The symptoms of antibiotic-related diarrhea, bloating and abdominal pain and the incidence of AIGD were evaluated 7 days and 8–14 days after antibiotic use, with 10 patients in each group. 16S rDNA sequencing was performed to detect changes of the gut microbiota.ResultsWithin 7 days of the initiation of antibiotic treatment, the incidences of AIGD in the control group, regular group (840 mg of BIFICO), and double-dosage group (1680 mg of BIFICO) were 21.88%, 14.93%, and 6.15% respectively. On days of 8–14th, the incidences of AIGD in the control group, regular group, and double-dosage group were 25%, 14.93%, and 4.62%, respectively. The incidence of AIGD in the double-dosage group within 7 days and 14 days were both significantly lower than that in relevant control group (P < 0.05). On day 14, the incidence of AIGD in the double-dosage group was lower than that in the regular group (P < 0.05). The number of operational taxonomic units (OTUs) in the control group after antibiotic treatment was significantly reduced compared to that prior to treatment, while those of the regular and double-dosage groups were stable. The species abundance, especially Parabacteroides, Phascolarctobacterium and Roseburia, of the double-dosage group was greater than that of the regular group and the control group.ConclusionsBIFICO may reduce the occurrence of AIGD in a dose-dependent manner and can stabilize the gut microbiota balance.
Highlights
The aim of this study is to evaluate the prophylactic effects of probiotic mixture BIFICO on antibioticinduced gut dysbiosis (AIGD) and the influence on the change of the gut microbiota
The characteristics of the patients were well balanced among the three study groups, that there were no significant differences in ages, levels of inflammation markers (WBC, CRP, PCT), length of hospitalization, duration of antibiotic usage, types of antibiotic (Table 1)
The incidence of AIGD was reduced in the double-dosage group (6.2%) at an early stage compared to that of the control group (P < 0.05)
Summary
The aim of this study is to evaluate the prophylactic effects of probiotic mixture BIFICO on antibioticinduced gut dysbiosis (AIGD) and the influence on the change of the gut microbiota. Antibiotics kill or inhibit pathogenic bacteria to treat countless patients [1]. Antibiotics can kill bacteria that normally colonize the human body, such. Antibiotic-mediated gut dysbiosis are related to diverse pathological conditions, including obesity, type 2 diabetes, inflammatory bowel disease, anxiety, autism, allergies, and autoimmune diseases [6], hippocampal neuroglial reorganization and depression [7], alzheimer’s disease [8]. This increases medical costs and the length of hospitalization as well as severely threatens the lives of patients. Most of the related studies are clinical observations and analyses [11, 12], and there have been very few studies focusing on how probiotics can affect or regulate the gut microbiota
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