The promoter regions of the T-cell receptor V9 γ (TRGV9) and V2 δ (TRDV2) genes display short direct repeats but no TATA box

Abstract

T lymphocytes expressing the T-cell γδ receptor have been shown to express preferentially the T-cell receptor V9 γ(TRGV9) gene, in association with the T-cell receptor V2 (δ(TRDV2) gene. In this paper, we report that the promoter regions of the TRDV2 and TRGV9 genes, which are preferentially expressed early in T-cell differentiation, display short direct repeats but no TATA box, in contrast to the Vγ genes belonging to subgroup I. The TCCTCAGT octanucleotide found 100 pb upstream of the ATG of the HD-Mar Vα transcript, a TcR Vα gene without a TATA box, is observed upstream of TRDV2 but not TRGV9. Of interest is the presence of a characteristic decanucleotide AGGTGGT(T)GAG in the promoter regions of both the TRDV2 and TRGV9 genes. Promoter region; Receptor, γ T-cell; Receptor, δ T-cell; Gene, variable; Transcription; (Human)