Abstract
Gliomas, particularly high-grade gliomas like glioblastomas, represent some of the most formidable challenges in oncology. These brain tumors are notorious for their resistance to conventional therapies, including surgery, chemotherapy, and radiation. The recent systematic review and meta-analysis protocol offers a promising direction by focusing on Tumor Mutation Burden (TMB) and Tumor Microenvironment (TME) as potential biomarkers for treatment outcomes and prognosis in gliomas.
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