Abstract
Background. Inthispaper,weprovidebackgroundandcontext regarding the potential for a new data-sharing platform, the ProjectDataSphere(PDS)initiative,fundedbyfinancialandinkind contributions from the CEO Roundtable on Cancer, to transform cancer research and improve patient outcomes. Giventherelativelymodestdeclineincancerdeath ratesover the past several years, a new research paradigm is needed to accelerate therapeutic approaches for oncologic diseases. Phase III clinical trials generate large volumes of potentially usable information, often on hundreds of patients, including patientstreatedwithstandardofcaretherapies(i.e.,controls). Both nationally and internationally, a variety of stakeholders have pursued data-sharing efforts to make individual patientlevel clinical trial data available to the scientific research community.
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