Abstract
BackgroundIntracerebral hemorrhage (ICH) is fatal and detrimental to quality of life. Clinically, options for monitoring are often limited, potentially missing subtle neurological changes. Integrin β 1 (ITGB1) and β 3 (ITGB3) are the main components of integrin family receptors, which regulate the formation and stability of blood vessels. This study explored the relationship between the expression of ITGB1 and ITGB3 in intracerebral hemorrhage (ICH) to analyze their functional and clinical relevance.MethodsThe expression of ITGB1 and ITGB3 in ICH was accomplished by immunohistochemical (IHC) staining and western blotting (WB) analysis, respectively.ResultsFurthermore, the results demonstrated that ITGB1 was expressed in ICH tissues, but ITGB3 was not expressed in ICH tissues.ConclusionsIn summary, the clinical progression of ICH was related to the expression of ITGB1. ITGB1 may be a potential biomarker and contribute to the treatment of ICH.
Highlights
Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life
Comparison of general clinical data of patients with stroke The expression of ITGB1 and ITGB3 in tissue samples of patients with ICH was detected by IHC staining
Suggests that ITGB1 was expressed in different parts of ICH tissues
Summary
Intracerebral hemorrhage (ICH) is fatal and detrimental to quality of life. This study explored the relationship between the expression of ITGB1 and ITGB3 in intracerebral hemorrhage (ICH) to analyze their functional and clinical relevance. ECM participates in the interaction between cells through the mediation of integrins [11]. Once the nervous system is injured, integrins can affect (2021) 7:14 nerve regeneration by promoting the survival of neurons, regulating the length of nerve axons, and participating in the directional migration and differentiation of nerve cells [12]. Integrin β 1 (ITGB1) and β 3 (ITGB3) are the main components of integrin family receptors, which regulate the formation and stability of blood vessels [14,15,16]. Whether the injury of ICH leads to the alteration of ITGB1 and ITGB3 has not been confirmed
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