Abstract
Primary open angle glaucoma (POAG) is defined as an optic neuropathy characterized by loss of optic nerve axons and retinal ganglion cells. Increase of intraocular pressure (IOP) is a major risk factor for POAG, which is partially due to an abnormally high aqueous humor outflow resistance in trabecular meshwork (TM). Trabecular outflow pathway is a key element in drainage of aqueous humor. Malfunction of TM in POAG is associated with over expression of inflammatory markers, cellular senescence, oxidative stress, and decrease of cellularity. The biological changes of TM cell and extracellular matrix compromise trabecular pathway drainage resulting in an increased IOP. This article reviewed the progression in research on aqueous humor outflow pathway emphasizing the alteration of trabecular pathway.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
