Abstract
Aim To investigate the mRNA expression and clinical significance of structural maintenance of chromosomes protein 4 (SMC4) in breast cancer. Methods A total of 23 paired samples were sequenced, and data from the Cancer Genome Atlas were analyzed. Results SMC4 mRNA level was significantly upregulated in breast cancer tissues (P < 0.001). Patients with high mRNA expression of SMC4 had significantly poor survival (P = 0.012). Subgroup analyses show that in nontriple negative breast cancer (non-TNBC) patients, the high SMC4 mRNA expression, older age (>65), negative progesterone receptor, and advanced stages (III-IV) were independent risk factors (HR = 3.293, 95% CI 1.257-8.625, P = 0.015). In patients with TNBC, high mRNA expression of SMC4 correlated with better survival rate (P < 0.046). Conclusion SMC4 mRNA level is a good prognostic biomarker for patients with breast cancer.
Highlights
Breast cancer is the most prevalent cancer among women globally
Results showed that structural maintenance of chromosomes protein 4 (SMC4) mRNA expression was higher in all the 23 breast cancerous tissues than in all the 23 paired adjacent noncancerous tissues (Figure 1(a))
In the the Cancer Genome Atlas (TCGA) data, SMC4 mRNA expression was higher in cancerous tissues than in paired noncancerous tissues (P < 0:001) (Figure 1(b))
Summary
Breast cancer is the most prevalent cancer among women globally. Recent data shows that about 2,080,000 new cases of breast cancer are diagnosed yearly, while more than 626,000 patients are dying of this disease each year [1]. The evolution of molecular subtype classification has incentivized the design of more precise and effective therapies for patients. It has been reported that early surgical treatment of breast cancer leads to good prognostic outcomes. About 10% of patients experience metastasis before death within 5 years after surgery [2,3,4]. Identification of new biomarkers is needed to facilitate the development of more effective therapeutic strategies
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