Abstract
Background and Purpose: The systemic immune–inflammation index (SII) is a novel prognostic index in various diseases. We evaluated the predictive value of SII in patients with intracerebral hemorrhage (ICH).Methods: Patients with primary spontaneous ICH were enrolled. SII was constructed based on peripheral platelet (P), neutrophil (N), and lymphocyte (L) and defined as P*N/L. In addition to admission testing, acute phase SII was collected to analyze the potential dynamic change. Poor outcome was defined as modified Rankin Scale of more than 3 at 90 days.Results: We included 291 patients; 98 (34%) achieved favorable functional outcomes. Day-1 SII was higher and was more related to poor outcome than was admission SII. Median time of day-1 SII was 29 h from onset. Day-1 SII had an OR in outcome (mRS >3) 1.74 (95% CI = 1.03–3.00, p = 0.04). The binary cutoff point of SII calculated using the area under the curve (AUC) method was 1,700 × 109/L, AUC 0.699 (95% CI = 0.627–0.774) (sensitivity 53.3%, specificity 77.3%) (OR = 2.36, 95% CI = 1.09–5.26, p = 0.03).Conclusions: SII, especially day-1 SII, was highly associated with 90-day functional outcome in patients with ICH and could be used to predict outcomes.
Highlights
Spontaneous intracerebral hemorrhage (ICH) is associated with high mortality and poor outcome [1]
We evaluated the predictive value of systemic immune–inflammation index (SII) in patients with intracerebral hemorrhage (ICH)
The binary cutoff point of SII calculated using the area under the curve (AUC) method was 1,700 × 109/L, AUC 0.699 (OR = 2.36, 95% CI = 1.09–5.26, p = 0.03)
Summary
Spontaneous intracerebral hemorrhage (ICH) is associated with high mortality and poor outcome [1]. Systemic Index and Hemorrhage Stroke laboratory results that reflect inflammation have been reported to predict ICH outcome. The neutrophil–lymphocyte ratio (NLR) was reported [9, 10], as were PLT–lymphocyte ratio (PLR) [11], and lymphocyte– monocyte ratio (LMR) [12]. These studies showed that levels of inflammation are highly related to the clinical outcome following ICH [13]. We evaluated the predictive value of SII in patients with intracerebral hemorrhage (ICH)
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