Abstract
This study was aimed to examine the prognostic value of preoperative neutrophils, platelets, lymphocytes, monocytes and calculated ratios in patients with laryngeal squamous cell cancer (LSCC). From January 2007 to December 2011, 979 patients with LSCC were enrolled in our study. Preoperative neutrophils, platelets, lymphocytes, monocytes, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) were analyzed. Besides well-established clinicopathological prognostic factors, we evaluated the independent prognostic relevance of these hematological parameters by Cox regression models in disease-free survival (DFS) and cancer-specific survival (CSS). We found patients in the highest tertile of NLR (>2.40), PLR (>111.00) were at significantly higher risk of DFS and CSS (P<0.05) compared with those in the lowest tertile after multivariate analysis, whereas presenting significantly higher risk in the lowest tertile of lymphocytes (<1.60×109/L) and LMR (<3.50). Additionally, the tertile category of NLR as well as PLR increased and lymphocytes as well as LMR decreased in shorter DFS and CSS by the Kaplan-Meier method and the log-rank test. In conclusion, this study indicated that preoperative lymphocytes, NLR, PLR and LMR were significantly associated with LSCC progression, DFS and CSS, and these hematological parameters could be considered independent prognostic values for patients with LSCC.
Highlights
Laryngeal cancer is one of the most common head and neck cancers that remains as the remarkable cause of morbidity and mortality
This study evaluated the preoperative prognostic value of the comprehensive inflammatory absolute counts and calculated ratios (NLR, platelet-to-lymphocyte ratio (PLR) and lymphocyte-to-monocyte ratio (LMR)) for patients with laryngeal squamous cell cancer (LSCC)
Our study demonstrated that preoperative lower neutrophils, monocytes, platelets, neutrophil-to-lymphocyte ratio (NLR), PLR and higher lymphocytes as well as LMR correlated to LSCC progression, including tumor size, tumor stage and clinical stage
Summary
Laryngeal cancer is one of the most common head and neck cancers that remains as the remarkable cause of morbidity and mortality. The predominant histological type of laryngeal cancer is laryngeal squamous cell cancer (LSCC). The estimated incidence and mortality of laryngeal cancer were 26,400 and 14,500 cases in China in 2015 [1]. Conventional treatment options in LSCC have mainly included surgery, radiotherapy, chemotherapy either used alone or in combination [2], and the clinical classification system of the Union. Despite improvements in diagnostic approach and treatment, the previously identified trend in 5-year relative survival rates indicated that the clinical outcome for LSCC does not have significantly improved in the past thirty years (from 59.6% to 66.8%) [3]. Www.impactjournals.com/oncotarget it is of great significance to find out more parameters that can provide more efficient and useful information of prognosis after treatment
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
