Abstract
Recently, many studies have been conducted to explore prognostic value of platelet to lymphocyte ratio (PLR) for patients with lung cancer, while the results remain controversial. We collected pretreatment, clinicopathological and follow-up data of 1388 lung cancer patients receiving surgery between 2006 and 2011 in our hospital, and reviewed relevant articles from Embase, Pubmed, Web of science databases, then performed a meta-analysis to clarify the relationship between PLR and prognosis of lung cancer patients. Finally, 11 articles with our study were included, results indicated elevated PLR was negatively related to overall survival (HR = 1.33, 95% CI: 1.10–1.62), but not related to progress-free survival (HR = 1.21, 95% CI: 0.97–1.49). Subgroup analysis suggested high PLR was correlated with poor survival in non-small cell lung cancer (HR = 1.43, 95% CI: 1.14–1.78), but not in small cell lung cancer (HR = 1.10, 95% CI: 0.76–1.58). Besides, for patients treated by chemotherapy or radiotherapy (HR = 1.66, 95% CI: 1.15–2.38) and patients in late stage (HR = 1.41, 95% CI: 1.19–1.68), PLR had significantly prognostic value. Additionally, the result was significant for patients when cut-off value of PLR was between 150 and 200 (HR = 1.47, 95% CI: 1.18–1.82). In Conclusion, this meta-analysis revealed that elevated PLR was associated with poor prognosis in lung cancer.
Highlights
In these years, many studies have proved that systemic inflammation and immunology played important roles in the development and progression of various cancers
We found that gender, age, pathological type, TNM stage, platelet to lymphocyte ratio (PLR) were significantly related to survival
We found the pooled hazard ratio (HR) for patients receiving surgery was 1.20, while 1.66(95% confidence interval (CI): 1.15–2.38) for patients treated by chemotherapy or radiotherapy
Summary
Many studies have proved that systemic inflammation and immunology played important roles in the development and progression of various cancers. Platelet count was positively associated with metastasis of lymph nodes and negatively correlated with overall survival of patients with lung cancer[9], while reduced lymphocyte suggested poor prognosis in many cancers[10]. Number of platelet and lymphocyte, has been researched in many institutes to identify its association with survival of lung cancer patients in these years. We performed a retrospective study of a large consecutive cohort and conducted a meta-analysis aiming to systematically clarify the prognostic value of PLR in lung cancer
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