Abstract
It is reported recently Tropomyosin-related receptor Kinase B (TrkB) plays key roles in the anoikis resistance during the processes of tumorigenesis and metastasis. However, its prognostic significance for clinical patients remains inconclusive. In order to establish a correct and practicable link between increased TrkB and prognostication of human solid tumors, a meta-analysis was performed in this article. A systematic literature research in the electronic databases PubMed, Embase and Web of Science was performed to identify eligible studies. A fixed-effects meta-analytical model was employed to correlate TrkB expression with OS, DFS and clinicopathological features. A total of 11 studies covering 1516 patients with various solid tumors were recruited in this meta-analysis. TrkB over-expression was associated with poorer OS and poorer DFS in multivariate analysis. Additionally, the pooled odds ratios (ORs) indicated that TrkB over-expression was associated with large tumor size, lymph node metastasis, distant metastasis and a higher clinical stage. Overall, these results indicated that TrkB over-expression in patients with solid tumors might be related to poor prognosis and serve as a potential predictive marker of poor clinicopathological prognosis factor.
Highlights
Tianjin Key Laboratory of Food Science and Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, China
The results showed that increased Tropomyosin-related receptor Kinase B (TrkB) expression in patients with solid tumors related to poor prognosis and served as a potential prediction of poor clinicopathological prognosis factor
The clinical and pathological parameters collected from the eligible studies were presented in pooled results of the correlations were identified between over-expressed TrkB and clinicopathological features of patients with solid tumors
Summary
TrkB was originally defined as a specific suppressor of caspase-associated anoikis of nonmalignant epithelial cells. The vast bulk of the evidence from studies on solid tumor cells of liver, lung, breast and ovary indicated that anoikis suppression induced by over-expressed TrkB best owed enhanced metastatic capacity on various tumor cells [11,12,13,14]. The correlation between the expression of TrkB and patient survival remains inconclusive. We conducted a meta-analysis to investigate the significance of over-expressed TrkB in the prediction of prognosis of corresponding patients. The results showed that increased TrkB expression in patients with solid tumors related to poor prognosis and served as a potential prediction of poor clinicopathological prognosis factor.
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