Abstract
Cervical cancer is one of the most common malignancies in women worldwide. Numerous literatures demonstrate that aberrantly expressed lncRNAs are involved in tumorigenesis and development, and may have the potential to be prognostic markers. However, their prognostic functions in cervical remain controversial. Therefore, we performed this meta-analysis to evaluate the prognostic significance of lncRNAs in cervical cancer. We searched databases to identify relevant articles. Pooled hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated. 15 studies involving 1868 patients with cervical cancer and 12 lncRNAs were included. Our results indicated that the levels of lncRNAs were associated with the overall survival ((HR = 1.56, 95%CI = 1.02–2.38, P < 0.001, random-effect) and event free survival (HR = 1.33, 95%CI = 0.77–2.28, P < 0.01, random-effect). High HOTAIR expression was associated with shorter overall survival in cervical cancer (HR = 3.93, 95% CI = 2.34–6.62, P < 0.001, fixed-effect). In conclusion, our meta-analysis suggested that lncRNAs may serve as novel predictive factors for prognosis of cervical and high expression HOTAIR was associated with shorter overall survival in cervical cancer.
Highlights
Cervical cancer is the second most deadly gynecological cancer and caused about 260,000 women’s death each year [1]
Our results indicated that the levels of Long noncoding RNA (lncRNA) were associated with the overall survival ((HR = 1.56, 95%confidence interval (CI) = 1.02–2.38, P < 0.001, random-effect) and event free survival (HR = 1.33, 95%CI = 0.77–2.28, P < 0.01, random-effect)
Abnormal expression of multiple lncRNAs was found to be related with the tumorigenesis and may have the potential to be prognostic biomarkers and even therapeutic targets of cervical cancer [15, 30]
Summary
Cervical cancer is the second most deadly gynecological cancer and caused about 260,000 women’s death each year [1]. Radical surgery is recommended as the preferred treatment for patients with cervical cancer in early stage, producing a relatively favorable prognosis [2]. LncRNAs can regulate various biological processes, such as gene expression, transcription, and cellular proliferation, through epigenetic silencing, mRNA splicing, and lncRNA-microRNA interaction [5, 6]. By comparing their expression of tumors and normal cells, lncRNAs are abnormally expressed in the various tumors, functioning as oncogenes or tumor suppressors [7, 8]. With the aim to obtain a better understanding of the prognostic value of lncRNAs in patients with cervical cancer, we performed a meta-analysis to explore the prognostic value of lncRNAs through larger sample size of patients
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