Abstract
BackgroundColorectal cancer (CRC) is the third most prevalent cancer type and the third leading cause of cancer-related deaths worldwide, it is urgently needed to discover a new marker for the progress of CRC. Many long noncoding RNAs (lncRNAs) have been reported to be abnormally expressed in CRC, and may be feasible as effective biomarkers and prognostic factors. The aim of this study was to identify the prognostic value of various lncRNAs in CRC.MethodsPubmed, Web of Science, Embase and Cochrane Library were searched for potentially related studies. A total of 34 eligible studies including 30 on overall survival (OS), 7 on disease-free survival (DFS), 1 on relapse-free survival (RFS), 2 on disease-specific survival (DSS) and 29 on clinicopathological features were qualified from the databases.ResultsThe results showed that the expression levels of lncRNAs were significantly associated with poor OS (hazard ratio (HR) = 2.08, 95% confidence interval (CI) = 1.68–2.57, P<0.001, I2 = 70%), DFS (HR = 1.79, 95% CI = 1.54–2.08, P<0.001, I2 = 6%) and DSS (HR = 0.11, 95% CI = 0.02–0.54, P = 0.007, I2 = 14%). Subgroup analysis further showed that lncRNA transcription level was significantly associated with tumor differentiation (odds ratio (OR) = 0.51, 95% CI = 0.34–0.77, P = 0.001), lymph node metastasis (OR = 1.63, 95% CI = 1.23–2.17, P = 0.0007), distant metastasis (OR = 2.06, 95% CI = 1.29–3.30, P = 0.002), TNM stage (OR = 0.44, 95% CI = 0.32–0.62, P<0.001), tumor invasion depth (OR = 0.48, 95% CI = 0.39–0.60, P<0.001).ConclusionsThe meta-analysis demonstrated that abnormal lncRNA transcription level may serve as a promising indicator for prognostic of patients with CRC.
Highlights
Colorectal cancer (CRC) is one of the most common malignancies, which ranks the third in the cancer morbidity and the second in the cancer mortality worldwide, with an annual 1.3 million new CRC cancer cases and 694,000 deaths according to the GLOBOCAN estimations [1, 2]
The results showed that the expression levels of long noncoding RNAs (lncRNAs) were significantly associated with poor overall survival (OS) (hazard ratio (HR) = 2.08, 95% confidence interval (CI) = 1.68–2.57, P
Subgroup analysis further showed that lncRNA transcription level was significantly associated with tumor differentiation (odds ratio (OR) = 0.51, 95% CI = 0.34–0.77, P = 0.001), lymph node metastasis (OR = 1.63, 95% CI = 1.23–2.17, P = 0.0007), distant metastasis (OR = 2.06, 95% CI = 1.29–3.30, P = 0.002), Tumor node metastasis (TNM) stage (OR = 0.44, 95% CI = 0.32–0.62, P
Summary
Colorectal cancer (CRC) is one of the most common malignancies, which ranks the third in the cancer morbidity and the second in the cancer mortality worldwide, with an annual 1.3 million new CRC cancer cases and 694,000 deaths according to the GLOBOCAN estimations [1, 2]. Relapse and metastasis are major factors for the poor outcome of CRC patients[5]. Accumulating evidences showed that lncRNAs played pivotal roles in various cancers and were associated with tumor cell proliferation, apoptosis, invasion and metastasis[10, 11]. LncRNA H19 was significantly up-regulated in the plasma of Gastric Cancer (GC) patients, and could be a potential non-invasive diagnostic biomarker in GC[13]. In non-small cell lung cancer, upregulation of long non-coding RNA ATB, a TGF-β-activated lncRNA, indicated a poor prognosis by regulating cell proliferation and metastasis[15]. Recent mounting studies have shown that lncRNAs are potential diagnostic and prognostic biomarkers of CRC. Many long noncoding RNAs (lncRNAs) have been reported to be abnormally expressed in CRC, and may be feasible as effective biomarkers and prognostic factors. The aim of this study was to identify the prognostic value of various lncRNAs in CRC
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