Abstract
4743 Background: The complex syndrome of cancer cachexia is multifactorial in origin and several cytokines may be involved in its aetiology. The present study was undertaken to evaluate the relationship between serum tumour necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and cachexia in patients with prostate cancer (CaP), and their prognostic significance. Methods: The levels of TNF-α and IL-6 were determined in serum samples from 26 patients with organ-confined CaP, from 54 patients with advanced or metastatic CaP and from 38 controls. High sensitive commercially available (ELISA) assays were used to determine cytokine levels. Serum IL-6 and TNF-α levels were correlated with serum albumin levels, hemoglobin levels, body mass index, clinicopathological variables and patient survival. The prognostic significance of the above parameters was assessed using univariate and multivariate Cox's proportional hazards model analyses. Results: Weight loss more than 10% over a 3–6 month period was seen in 7 of 54...
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