Abstract
目的探讨成人Ph染色体阴性急性淋巴细胞白血病(Ph−ALL)诱导治疗第14天(D14)骨髓原始细胞比例与获得完全缓解(CR)和预后的关系。方法回顾分析166例初治Ph−ALL患者,通过ROC曲线确定影响诱导治疗4周达CR的D14骨髓原始细胞比例。结果166例Ph−ALL患者,男94例,女72例,中位年龄32(18~64)岁。诱导治疗4周CR率为74.7%,总CR率为93.3%。存活者中位随访32(2~175)个月,5年无病生存(DFS)和总体生存(OS)率分别为45.6%和47.2%。D14骨髓原始细胞≥0.075组与<0.075组相比,4周CR率(42.7%对85.9%,P<0.001)和总CR率(75.9%对95.6%,P=0.001)显著降低,5年DFS率(29.6%对49.8%,P=0.006)和OS率(32.6%对52.4%,P=0.010)均显著降低。多因素分析显示,发病时高白细胞计数、存在中枢神经系统白血病、D14骨髓原始细胞≥0.075、诱导治疗4周未达CR、CR后接受化疗而非移植是影响DFS和OS的不利因素。结论成人Ph−ALL患者诱导化疗D14骨髓原始细胞比例较高是影响获得CR和总体预后的不利因素。
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
More From: Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.