Abstract
Objective: to assess the influence of the myxoid matrix in retroperitoneal well-differentiated liposarcoma(WDLPS ) on the long-term results of surgical treatment of patients.Material and Methods. The study included 111 patients with primary retroperitoneal WDLPS who underwent radical surgical treatment in Federal State Budgetary Institution «N.N. Blokhin National Medical Research Center of Oncology» of the Ministry of Health of the Russian Federation. Histological slides of all surgical specimens were reviewed by experienced pathologist and reclassified according to criteria of WHO (2013) for histological subtypes of the WDLPS . Patients were divided into groups depending on presence or absence of the myxoid matrix in WDLPS and enrolled in intergroup analysis of overall (OS ) and recurrence-free (RFS) survival.Results. OS was significantly worse in the group of patients with the myxoid matrix in the tumor (p=0.002; log-rank test). The median OS was 142 (95 % CI , 108, 176) months in the group without the myxoid matrix, and 84 (95 % CI , 29, 139) months in the group with the myxoid matrix. The 5-year survival rates were 79 % and 44 % in the groups without myxoid matrix and with myxoid matrix, respectively. RFS was also significantly worse in the group of patients with the myxoid matrix than in the group of patients without the myxoid matrix (p=0.006; log-rank test). The median RFS was 55 (95 % CI , 38, 72) months in the WDLPS group without the myxoid matrix, and 31 (95 % CI , 15, 47) months in the WDLPS group with the myxoid matrix. The 2-year RFS rates were 75 % and 44 % in the groups without the myxoid matrix and with the myxoid matrix, respectively.Conclusion. The results of the study demonstrated that the presence of the myxoid matrix in WDLPS was associated with poor prognosis. We believe that the presence of the myxoid matrix in WDLPS can serve as an effective morphological marker of a less favorable prognosis for retroperitoneal WLPS .
Highlights
Согласно последней классификации опухолей костей и мягких тканей ВОЗ (2013), ВДЛПС подразделяются на 3 гистологических варианта: 1) липомоподобный – опухоль преимущественно или полностью представлена жировой тканью, гистологически сходной с неизмененной жировой тканью или липомой; 2) склерозирующий – большая часть липогенной опухоли представлена полями коллагена с низким содержанием стромальных клеток без признаков липогенной дифференцировки
Histological slides of all surgical specimens were reviewed by experienced pathologist and reclassified according to criteria of WHO (2013) for histological subtypes of the well-differentiated liposarcoma (WDLPS)
Patients were divided into groups depending on presence or absence of the myxoid matrix in WDLPS and enrolled in intergroup analysis of overall (OS) and recurrence-free (RFS) survival
Summary
Волков Александр Юрьевич, аспирант онкологического отделения хирургических методов лечения No 6 (абдоминальной онкологии), ФГБУ «НМИЦ онкологии им. Козлов Николай Александрович, кандидат медицинских наук, врач-патологоанатом патологоанатомического отделения отдела морфологической и молекулярно-генетической диагностики опухолей, ФГБУ «НМИЦ онкологии им. Неред Сергей Николаевич, доктор медицинских наук, ведущий научный сотрудник онкологического отделения хирургических методов лечения No 6 (абдоминальной онкологии), ФГБУ «НМИЦ онкологии им. Россия); заведующий онкологическим отделением хирургических методов лечения No 6 (абдоминальной онкологии), ФГБУ «НМИЦ онкологии им. Строганова Анна Михайловна, кандидат биологических наук, заведующая молекулярно-генетической лабораторией отдела морфологической и молекулярно-генетической диагностики опухолей, ФГБУ «НМИЦ онкологии им. Архири Петр Петрович, кандидат медицинских наук, врач-хирург онкологического отделения хирургических методов лечения No 6 (абдоминальной онкологии), ФГБУ «НМИЦ онкологии им. Антонова Елена Юрьевна, аспирант отделения лекарственных методов лечения (химиотерапии No 17), ФГБУ «НМИЦ онкологии им.
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