Abstract
Our study aimed to investigate the association between metabolic syndrome and postoperative survival in patients with esophageal squamous cell carcinoma, and evaluate whether metabolic syndrome can predict the prognosis in esophageal cancer patients. The retrospective study reviewed 519 patients with esophageal squamous cell carcinoma who had received esophagetomy and lymphnode dissections in the Department of Thoracic Surgery, Qilu Hospital of Shandong University between January 2007 and December 2011. All patients were followed up until December 2016. The median follow-up time was 39.59 months (range 0.25–72 months). The 3-year and 5-year survival rate was 51.4% and 37.0%, respectively. Kaplan–Meier survival analysis revealed a significant correlation between OS and obesity (P = 0.000), weight loss (P = 0.000), diabetes (P = 0.001) and dyslipidemia (P = 0.030). Multivariate analysis indicated that advanced TNM staging (P = 0.007, HR: 1.760, 95% CI: 1.167–2.654) and more weight loss (P = 0.000, HR: 1.961, 95% CI: 1.697–2.267) were independent factors for adverse prognosis of esophageal squamous carcinoma patients. In contrast, diabetes was a protective factor in the prognosis of patients with esophageal cancer (P = 0.018, HR: 0.668, 95% CI: 0.478–0.933). Our findings suggest that TNM staging, weight changes and diabetes were independent predictors for the prognosis of esophageal cancer patients.
Highlights
Esophageal cancer (EC) is one of the most common malignant gastrointestinal tumors in the world
Diabetes was a protective factor in the prognosis of patients with esophageal cancer (P = 0.018, HR: 0.668, 95% CI: 0.478–0.933)
It was shown that TNM stage (P = 0.008, HR: 1.643, 95% CI: 1.140–2.369), weight loss (P = 0.000, HR: 1.674, 95% CI: 1.462–1.917) and dibetes (P = 0.027, HR: 0.691, 95% CI: 0.499–0.958) were independently associated with progression-free survival (PFS)
Summary
Esophageal cancer (EC) is one of the most common malignant gastrointestinal tumors in the world. Some studies have indicated that certain factors in MS were associated with risk of cancer, including liver, colorectal, bladder, pancreatic, breast and esophageal cancer[10,11,12]. Several studies have shown that preoperative weight loss in esophageal cancer resection might have a certain relationship with postoperative survival[14,15]. The effects of MS and its related factors on overall survival (OS) and progression-free survival (PFS) of esophageal cancer need to be further discussed. We conducted this retrospective study to investigate the relationship between MS, weight loss and postoperative survival in patients with ESCC, and evaluate whether MS or weight loss can predict the prognosis in esophageal cancer patients
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