Abstract
The Prognostic Role of Magnetic Resonance Imaging Biomarkers in Mild Traumatic Injury
Highlights
In this study by Richter et al,[2] the authors present the results of a prospective multicenter observational study that included patients from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-Traumatic brain injury (TBI)) to study the association of white matter changes detected on diffusion tensor imaging (DTI) with persistent symptoms after mild TBI
An early paradoxical increase in FA can still occur in the early phase after mild TBI due to transient axonal swelling and loss, in areas of crossing fibers, and changes related to Wallerian degeneration.[4]
A study by Eierud et al[5] reported that the association between DTI metrics and clinical symptoms may be time dependent, with lower neuropsychological performance correlating with higher anisotropy in the acute phase and lower anisotropy in later phases
Summary
In this study by Richter et al,[2] the authors present the results of a prospective multicenter observational study that included patients from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) to study the association of white matter changes detected on diffusion tensor imaging (DTI) with persistent symptoms after mild TBI. The study by Richter et al[2] provides further evidence that there is an association between structural changes detected on DTI, such as decreased FA and increased MD, and symptom severity and persistence.[3] an early paradoxical increase in FA can still occur in the early phase after mild TBI due to transient axonal swelling and loss, in areas of crossing fibers, and changes related to Wallerian degeneration.[4] A study by Eierud et al[5] reported that the association between DTI metrics and clinical symptoms may be time dependent, with lower neuropsychological performance correlating with higher anisotropy in the acute phase and lower anisotropy in later phases.
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