Abstract
Introduction: Breast cancer is one of the common malignant tumors in women. The use of biomarkers ensures breast cancer patients receive optimal treatment. Tumor-infiltrating lymphocytes (TILs) are emerging as one of the key prognostic markers of breast cancer. Our study aims to evaluate percentage of TILs in Objectives And Methodology: tumor tissue, grading TILs based on the recommendations by an International TIL Working Group 2014 & compare with ER & PR status and in relation to concentration of TILs we assess prognosis of breast carcinoma for a period of 6 months. Results: Among 30 study subjects, TILs were of intermediate, high & lower grade in 53.3%, 40% and 6.7% cases respectively. TILs expression was statistically significant in both ER and PR, positive & negative groups (p<0.05). TILs were statistically highly significant as a prognostic marker in hormone negative breast cancers (p<0.05). Conclusion: Our study concludes that high TILs are correlated with favourable survival and response to treatment in breast cancer patients with ER, PR negative molecular subtype
Published Version
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