Abstract
Objective. To analyze the treatment outcomes of patients who accepted IVF/ICSI-ET, diagnosed POR according to Bologna criteria. Study Design. Retrospective cohort study of one reproductive medical center, from 1st Jan., 2009, to 31st Dec., 2014. All patients fulfilled the Bologna criteria and accept IVF/ICSI-ET treatment with stimulation cycle. The main outcome measures were clinical pregnancy rate (CPR) and live birth rate (LBR). Results. There were 5770 eligible cycles included in this study. The incidence of POR was 10.3% (6286/62194). The overall CPR was 18.7%, IR was 11.6%, LBR/ET was 11.5%, and LBR/OPU was 8.3%. The cycle cancellation for no available oocyte or embryo was 4.9% and 18.6%, respectively. The subgroup of younger POR patients got highest CPR and LBR/ET, which decreased while increasing maternal age. Within three attempts, the patients got similar CPR and LBR. Conclusion. In conclusion, our study supports the Bologna criteria that defined women with poor IVF outcomes. But those younger than 42 years old with the first 3 attempts of IVF could got acceptable CPR and LBR.
Highlights
The number of infertile couples is increasing year by year around the world; more and more couples rely on in vitro fertilization and embryo transfer (IVF-ET) to achieve pregnancy and get their babies
The definition of poor ovarian response (POR) was quite different from different clinicians, and there were more than 40 different definitions that have been reported [4, 5]
Inclusion criteria were as follows: infertility couples underwent IVF/ICSI-ET that fulfilled the Bologna criteria [2], that is, at least two of the following three features must be present: (1) advanced maternal age (⩾40 years) or any other risk factor for POR; (2) a previous POR (⩽3 oocytes with a conventional stimulation protocol); and (3) an abnormal ovarian reserve test (i.e., AFC, 5–7 follicles or AMH, 0.5–1.1 ng/mL)
Summary
The number of infertile couples is increasing year by year around the world; more and more couples rely on in vitro fertilization and embryo transfer (IVF-ET) to achieve pregnancy and get their babies. In IVF treatment, poor ovarian response (POR) to controlled ovarian stimulation (COS) is a frustrating condition that represents a topic of utmost clinical and scientific relevance [1,2,3]. Lots of researches had been conducted to investigate the most suitable management for those POR patients but were still controversial. The success rate of those women was quite low, and large RCTs were hard to conduct to obtain reliable data. The lack of RCTs and the heterogeneity of the studied populations make it difficult to conduct high quality meta-analysis or get reliable conclusion
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