The prognosis of acute post infectious glomerulonephritis in adults: a long-term prospective study

Abstract

The contributions of pre-selected predictions of outcome for survival and renal function following acute post infectious glomerulonephritis were tested in a group of 41 adults, followed up for a mean of 13 years 5 months (range: 2 weeks to 15 years 2 months), using a proportional hazards model. The best predictor of outcome was the severity of the renal lesion, as judged by histology obtained at renal biopsy. The extent of functional deterioration during the acute phase and the aetiology were also related to outcome, though less significantly. Other variables including sex, age, race and the presence or absence of hypertension during the acute phase did not appear in this model to have an important bearing on prognosis, whether the latter was determined by patient and renal survival or by the extent of renal functional deterioration in survivors.