Abstract
Infection with Pasteurella multocida (P. multocida) causes severe epidemic diseases in rabbits and is responsible for the pronounced economic losses in the livestock industry. Long non-coding RNAs (lncRNAs) have been proven to exert vital functions in regulating the host immune responses to bacterial attacks. However, little is known about how lncRNAs participate in the rabbit's immune response against P. multocida infection in the lungs. LncRNA and mRNA expression profiles were analyzed by transcriptomics and bioinformatics during P. multocida infection. A total of 336 lncRNAs and 7,014 mRNAs were differentially regulated at 1 day and 3 days post infection (dpi). Nearly 80% of the differentially expressed lncRNAs exhibited an increased expression at 3 dpi suggesting that the P. multocida genes are responsible for regulation. Moreover, GO and KEGG enriched analysis indicated that the immune-related pathways including pattern recognition receptors (PRRs), cytokines, and chemokines were significantly enriched at 3 dpi. These results indicate that the dysregulated immune-related genes may play crucial roles in defending against P. multocida attacks. Overall, these results advance our cognition of the role of lncRNAs and mRNAs in modulating the rabbit's innate immune response against P. multocida attacks, which will offer a valuable clue for further studies into exploring P. multocida-related diseases in human.
Highlights
Pasteurella multocida (P. multocida) is a notorious Gram-negative opportunistic pathogen that is ubiquitous in the respiratory tracts of different animal species and results in enormous economic losses [1, 2]
Owing to the development of a convenient highthroughput sequencing technology and the progress of reliable bioinformatics, regardless of mRNAs, increasing noncoding RNAs (ncRNAs), such as miRNAs and Long non-coding RNAs (lncRNAs), especially lots of novel ncRNAs were discovered at the transcriptional level, which provides a new perspective for clarifying the molecular pathogenesis mechanisms and unique biological process (BP) of host-pathogen interactions [32]
For the first research of lncRNAs in P. multocida attacks of rabbits, we found that certain lncRNAs and mRNAs were significantly dysregulated
Summary
Pasteurella multocida (P. multocida) is a notorious Gram-negative opportunistic pathogen that is ubiquitous in the respiratory tracts of different animal species and results in enormous economic losses [1, 2]. It can be sorted into five serogroups (A, B, D, E, and F) and 16 Heddleston serotypes based on its capsular antigens and lipopolysaccharide (LPS) antigens [2, 3]. Profiles of Pasteurella multocida Attacks infections, which have been transmitted via licking or biting from rabbits, have raised substantial concern [6, 7].
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