Abstract
Intestinal dendritic cells (DCs) are key regulators of intestinal immune homeostasis. We studied the mononuclear phagocyte (MNP) subsets of the murine ileum and mesenteric lymph nodes in a mouse model of Schistosoma mansoni‐induced inflammation. Intraperitoneally injected, fluorescently labeled S. mansoni‐related antigens, i.e. soluble worm proteins as well as soluble egg antigens, were preferentially taken up by CX3CR1+ and F4/80+ MNPs and not readily observed in other MNP populations. Using a combination of immunohistochemistry and multiparametric flow cytometry, we demonstrated a significant increase in CD11c+CX3CR1+F4/80‐ DCs in the ileal lamina propria and the mesenteric lymph nodes during schistosomiasis. Our results point to an important role of CD11c+CX3CR1+F4/80‐ DCs in the immune response to trematode infection, lending support to the presumed role of these cells as specialized sentinel cells of the intestinal lamina propria.
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