Abstract
Research on the manufacture of nanoparticles of chitosan through top-down method has a limited publication. Most of the research on chitosan nanoparticles was conducted by ionic gelation and other methods. Therefore, this study aimed to investigate the characteristics of nanoparticles chitosan through top-down method. The rprocedure was composed using High Energy Milling (HEM) with different sizes of ball and milling time. The responses observed from this research were particle sizes, yield, viscosity and zeta potential. The results showed that milling time significantly affected the particle size. Milling time between 3 to 5 hour produce the particle size close to 200 nm. Milling duration for 5 hours with a small ball size produced shrimp chitosan nanoparticles with the value of 248.28 nm particle size, zeta potential mV of 44.92, yield of 96% and 104.88 cP viscosity. The nanoparticle produced was categorized as relatively stable because its zeta potential values were around ± 30 mV.
Highlights
Chitosan is a chitin derivative compound that has undergone a deacetylation process
Chitosan is used as drug carrier due to their ability to reach the side of therapeutic action (3)
The yield of shrimp nano chitosan ranged from 95.25% -98.01%
Summary
Chitosan is a biopolymer that is widely used in various industries as a coagulant in wastewater treatment, metal ion adsorbent, anti-cancer / anti-tumor, and food preservatives [1, 2]. Those advantages of chitosan make this polymer globally used as a raw material in many industries, for example in pharmaceutical industry. Its larger particle limits the utilization and the ease of chitosan application. Nanoparticle chitosan has received great attention because of their nano-size, large surface area, biodegradable, and good biocompatibility [4]
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