Abstract
The intensity and duration of Mullerian Inhibiting Substance (MIS) secretion by the fetal newborn and adult rat testes and the effect of the placenta and pituitary on the secretory pattern was studied in vivo and in vitro. A graded organ culture assay was used to determine the secretory pattern. Production of MIS was evident during the last trimester of pregnancy. MIS production continued during the 1st 3 weeks of neonatal life and then disappeared around the time of weaning. Hypophysectomy performed at 20 days of age failed to restore MIS activity in adult animals. Fragments of placenta in testis culture did not influence MIS activity in perinatal testes. MIS exhibited a regressive effect on Mullerian ducts placed at a distance from a testicular source.
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