Abstract
The phytopathogenic bacterium, Pseudomonas tabaci, produces, in culture, an exotoxin which, when purified, causes seizures in mice and rats. The syndrome is similar to that produced by methionine sulfoximine (L-MSO). However, the toxin is at least 10-fold or more potent than is L-MSO. As the concentration of the toxin administered intraperitoneally was increased, the average time to onset of convulsions decreased from 12 hours (0.0125 mmole) to 6 min (0.25 mmole). Intracisternal administration of the toxin to rats also produced convulsions. The convulsive effect of the toxin could not be reversed by l-methionine, which did reverse the convulsive effect of L-MSO.
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