Abstract
In mice, after a few days of oral treatment with antibiotics which are minimally absorbed, the bacterial fecal flora is eliminated. In the course of such treatment, the bacterial population of the skin becomes drastically reduced. After 9 weeks, cultures from the skin of the back are negative. Following 12 weeks of treatment, about 50% of the mice are shown to be persistently free of microbes that are detectable by conventional methods of culturing. Disinfection of the skin (chlorhexidine) on the fourth day of treatment had no effect on the time required to obtain negative “whole-body cultures” in these animals.
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