Abstract
La, Lb, R 1 and S-antigens in extracts of human and Aotus monkey blood infected with Plasmodium falciparum were inactivated by several proteolytic enzymes but were not affected by nucleases and selected carbohydrases. S-antigens also survived oxidation by periodate under conditions which inactivated a known carbohydrate-associated antigen. It was concluded that the L, R and S-antigens are proteins. Autoradiographic studies of extracts of parasitized red cells which had been maintained in vitro in the presence of radioactive amino acids, showed that various La, Lb and R-antigens were labelled but S-antigens were not. The incorporation of labelled amino acids into antigens derived from parasitized mature mammalian red cells was taken as evidence that these antigens were of parasite origin whcreas the unlabelled S-antigens might be of host origin.
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