Abstract
The mechanism of increased thromboplastin activity of the blood was studied on 100 patients operated on in connection with fibromyoma of the uterus and in 25 experiments with acute blood loss in dogs. The thromboplastin activity increased during the postoperative period by one and a half times, antithromboplastin activity by two and a half times. These changes occurred as soon as 2.5 hours after the operation, being most pronounced on the third day. The number of blood platelets increased insignificantly and only on the eighth postoperative day. Acute blood loss is associated with increased thromboplastin activity, reduction of antithromboplastin activity and a drop of the platelet count. The rise of the blood thromboplastin activity after the operations and blood losses are associated with reduced blood antithromboplastin activity. Increased blood thromboplastin activity, leading to accelerated blood coagulation, should be regarded as one of the manifestaions of “stress” reaction.
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