Abstract
Etiology and pathogenesis current concepts of the intermediate syndrome in cases of poisoning with anticholinesterase compounds (organophosphorus compounds, carbamates) are considered in the review. Characteristics of the syndrome clinical picture and its diagnostics methods using electromyography are presented.. Data on the experience of broadly used basic antidotal agents (cholinesterase reactivators, M – and N-cholinoreceptors) and pathogenic therapy of poisonings were analyzed and summarized. To solve the problem, priority research directions were determined, such as search for formation mechanisms of the nondepolarizing neuromuscular blocker and development of methods for prophylaxis and therapy using drugs targeting N-cholinoreceptors.
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