Abstract
It is known that there is a high risk of progression of side effects in kidneys, so-called nephropathy induced with X-ray contrast agents, at applying of water-soluble X-ray contrast agents in medical practice. New water-insoluble compounds of orthotantalates of rare-earth elements are offered as new X-ray contrast agents for endocavitary administration. The achieved results have shown the absence of general toxic effect on bodies of animals, high X-ray contrast properties in vitro and in vivo experiments. The investigations were performed on white nondescript mice, rats Wistar subtype and Chinchilla rabbits.
Highlights
Side effects with the use of the X-ray contrast agents
The sides effects (SE) of application of water-soluble X-ray contrast agents (XCA) are observed for 5-8% of patients, and severe complications occur for 0.1% of patients
We found little statistical information about SE associated with the use of water-soluble Iodine-containing XCA (ICXCA) in endocavitary administration routes during X-ray examination: cholangiography (CG), oral duodenography, pyelography, cystography etc
Summary
Iliya Mikhailovich Strekalov, Leonid Petrovich Larionov, Мikhail Georgievich Zuev, Elena Yuryevna Zhuravleva. To cite this article: Iliya Mikhailovich Strekalov, Leonid Petrovich Larionov, Мikhail Georgievich Zuev, Elena Yuryevna Zhuravleva. The Problem of Nephropathy Induced by Endocavitary Administration of Iodine-Containing X-ray Contrast Agents.
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