Abstract
Aim. To study the possibility of enhancing the antianginal effect of long-acting nitrates by their combination with trimetazidine in patients with stable angina. Material and methods. Patients with ischemic heart disease (IHD, stable angina; n=55) were included into the study. Patients were randomized to receive trimetazidine 35 mg 2 times a day (intervention group) or placebo (control group) in addition to standard therapy. A daily number of angina attacks, amount of short-acting nitroglycerin tablets consumed per week, exercise tolerance by the bicycle ergometry with the calculation of the threshold power and the work capacity were assessed at baseline and after 2 months of the drugs taking, as well as 2 months after the drugs withdrawal. Results. Significant reduction in nitroglycerin tablets consumption (1 month — by 61.8%, after 2 months — 72.5%, p<0.05) were found in the intervention group compared with the control group. Low intake of nitroglycerin compared with baseline (p<0.05) was maintained for 2 months after discontinuation of study drug. Significant increase in the threshold power (1 month — by 32.3%, after 2 months — 37.5%, p<0.05) was observed in the intervention group compared to baseline and with the control group. Conclusion. Trimetazidine in the treatment of stable angina has high clinical efficacy.
Highlights
По имеющимся у нас данным, это первое в России исследование по сравнительной оценке комплексного фармакологического вмешательства, которое основано на применении либо оригинальных препаратов, либо соответствующих дженериков для лечения больных со стабильным течением ишемической болезнью сердца (ИБС)
Доказанное свойство триметазидина оказывать положительное действие на уменьшение образования свободных радикалов, недоокисленных продуктов обмена, а также способность регулировать активность ключевого этапа энергетического метаболизма миокарда — бетаокисления свободных жирных кислот, по-видимому, и являются факторами, объясняющими усиление антиангинальной эффективности пролонгируемых нитратов у больных стабильной стенокардией
Summary
Изучить возможность усиления антиангинальной эффективности пролонгированных нитратов у больных стабильной стенокардией путем их комплексного применения с триметазидином. Aim. To study the possibility of enhancing the antianginal effect of long-acting nitrates by their combination with trimetazidine in patients with stable angina. В качестве препарата для метаболической терапии при стабильной стенокардии напряжения.
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