Year-end Sale % OFF 
Abstract
Diabetes is a disease that affects many people around the world. Its complications are the cause of cardiovascular diseases (CVD) and increased mortality. That is why the search for predictive biomarkers is so important. The aim of the study was to show the prevalence of the problem and risk factors in children and adolescents with type 1 diabetes. These patients are often overweight and obese, and the percentage of lipid disorders is particularly high. The discussed markers of CVD risk in type 1 diabetes include apolipoproteins (apo-B and apo-C3), modified forms of LDL, and the role of high-density lipoprotein (HDL). Recently, a new look at the vasoprotective effect of HDL has appeared, which due to its dysfunctional form in type 1 diabetes may not protect against cardiovascular risk. The HDL proteome in type 1 diabetes has an altered protein composition compared to the healthy population. Another direction of research is determining the importance of trace elements (mainly Mg) in the development of diabetes complications.
Highlights
Prevention of chronic complications of diabetes is of great significance and continues to challenge many professionals
There are reports suggesting that high-density lipoprotein (HDL), commonly regarded as a vasoprotective particle, does not provide protection against cardiovascular risk in type 1 diabetes due to its dysfunctional form [1, 15]
In order to be able to take even more targeted and effective action in the future to prevent the chronic complications of diabetes early, further research is needed to better identify predictive biomarkers
Summary
Prevention of chronic complications of diabetes is of great significance and continues to challenge many professionals. The duration and severity of hyperglycemia are the main factors causing tissue damage and contribute to the development of complications including both microangiopathies (retinal, glomerular, or nerve dysfunction) and macrovascular complications (earlier occurrence of more advanced atherosclerotic changes). Premature atherosclerosis of the arteries, which is the cause of cardiovascular diseases (CVD), is considered to be the main risk factor of almost three times higher mortality in type 1 diabetes [1, 2]. Advanced complications of diabetes mellitus, such as severe visual impairment, renal replacement therapy, consequences of neuropathy, or sexual dysfunction, restrict patients socially and deteriorate their quality of life. The aim of this article is to present the current knowledge about known risk factors for cardiovascular diseases as well as to present the directions of searching for new markers
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
