The Probiotics in Pediatric Asthma Management (PROPAM) study: A Post Hoc analysis in allergic children

Abstract

Type 2 inflammation is prevalent in children with asthma and increases susceptibility to respiratory infections.1 Furthermore, acute airway infections usually precede asthma exacerbations in children.2 Consequently, an ideal therapeutic strategy should be targeted to dampen inflammation and prevent infections. There is also evidence to suggest that children with asthma have intestinal and respiratory dysbiosis that promotes airway inflammation and allergy.3 It is speculated that probiotics could restore “eubiosis,” dampen inflammation, and prevent infections.