The principles of drug gastroduodenal bleeding prevention in critically ill condition patients and in postoperative period patients

Ye A Sorokina,S A Kopeikin,V B Loyenko,N A Morova,V V Safechuk

doi:10.20538/1682-0363-2010-6-133-140

Abstract

The basic pathogenic mechanisms of ulcer formation in critically ill condition patients and in postoperative period patients are studied in the article. The role of central nervous system, humoral effects, drug aggression, system inflammatory response and also acid peptic factor as a key mechanism of damage is introduced. The basic reasons for preventive maintenance of the gastroduodenal bleedings is represented considering the character and degree of disease, time of hardwired vital functions replacement, presence of further diseases. The conception is developed, which assuming the proton pump inhibitors application for a long time (till one month) in two phases (intravenous and peroral) for prevention of stress relative gastroduodenal mucosal damage and its consequences.

Highlights

The principles of drug gastroduodenal bleeding prevention in critically ill condition patients and in postoperative period patients
The basic pathogenic mechanisms of ulcer formation in critically ill condition patients and in postoperative period patients are studied in the article
The conception is developed, which assuming the proton pump inhibitors application for a long time in two phases for prevention of stress relative gastroduodenal mucosal damage and its consequences

Summary

Introduction

The principles of drug gastroduodenal bleeding prevention in critically ill condition patients and in postoperative period patients. Представлены основные патогенетические механизмы формирования язв гастродуоденальной зоны у пациентов, находящихся в критических состояниях, а также послеоперационном периоде различных хирургических вмешательств.

Results

Conclusion