THE PRIMARY RESULT OF RESEARCH ON THE SERUM HOMOCYSTEINE AND VITAMINE B12 CONCENTRATION IN ELDERLY PATIENTS WITH HYPERTENSION

Abstract

Objectives: To affirm the mean of serum homocysteine concentration in patient-control group. To affirm the mean of serum vitamine B12 concentration in patient-control group. To affirm the percentage of hyperhomocysteinemia in patient-control group. Methods: To affirm the serum homocysteine and vitamine B12 concentration in fasting (at least in 12 hours). To examine bilan lipid of the blood and to estimate some other risk factors in 128 elderly patients with hypertension (mean age ± 1SD, 72.4 ± 7.6, 60, 60 males, 68 females) and 132 control subjects (mean age ± 1SD, 71.8 ± 7.3, 63 males, 69 females) of similar age and sex were studied, corresponding, at the Tien Giang Central General Hospital (2017). Results: The mean of serum homocysteine concentration in patient group (18.46 ± 5.58 µmol/L) was higher than in control group (11.67 ± 2.65 µmol/L) (p<0.01). The mean of serum vitamine B12 concentration in patient group (539.64 ± 346.23pg/ ml) was the same in control group (556.86 ± 279.45pg/ml) (p>0.05). The percentage of hyperhomocysteinemia in patient group (71.88%) was higher than in control group (18.94%) (p<0.01). Conclusions: There was hyperhomocysteinemia in elderly patients with hypertension. The percentage of hyperhomocysteinemia in elderly patients with hypertension was higher than control group. Hyperhomocysteinemia in elderly patients with hypertension was a new risk factor of cardiovascular disease that is need to be controlled.