Abstract
reports of the isolation of small colony strains from disease processes. Chief among these is a report by Jacobsen' who cultured 50 specimens of blood and feces during an outbreak of typhoid fever in an insane asylum and obtained only 2 isolations. One of these from blood produced very fine colonies on agar, showed delayed acid reaction in mannite broth, and was not agglutinated by typhoid antiserum until after 4 months' cultivation on artificial mediums. From a feces culture plated on Conradi-Drigalski agar a second strain of E. typhosa was isolated which proved to be identical in its reactions with the first. Colonies were not visible at the end of 48 hours' incubation and were dis-
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