Abstract
There are several antioxidant supplements using for reproductivity and life quality, especially herbal ones. Nowadays, herbal antioxidants especially Spirulina platensis has been still interested due to protective role on oxidant antioxidant balance and health. The present study, we aimed to evaluate the effects of different doses of S.platensis on important oxidant molecule MDA (TBA, oxidant malondialdeyhde), and individual antioxidants as GPx (glutathione peroxidase), CAT (catalase) and SOD (superoxide dismutase) in healthy rats. For this purpose, we used thirty Wistar Albino male rats in three groups: Control, Low Dose Spirulina (500 mg kg-1) and High Dose Spirulina (1000 mg kg-1). S.platensis additives were given by oral gavage daily under a long forty five day of trial. At the end of the study, interestingly, all the antioxidants GPx, CAT, SOD and the oxidant MDA lipid peroxidation values were decreased in group high dose Spirulina compared to Control (p < 0.05). In spite of these decreases, testis weights and indexes were increased in group high dose Spirulina compared to Control significantly. The testis weights and indexes evaluated for normal health of animals. It can be considered that due to the excessive protein and antioxidants features of S.platensis, oxidant and antioxidant mechanisms may be changed. However it can be said that Spirulina can compensate the homeostasis and health of animals. It is also considered that the applications and different doses of S.platensis are needed to be assayed for further studies.
Highlights
Free radicals are important reactive molecules which designate for oxidative stress imbalance between oxidative and antioxidative status
The present study, we aimed to evaluate the effects of different doses of S. platensis on important oxidant molecule MDA (TBA, oxidant malondialdehyde), and individual antioxidants as glutathione peroxidase (GPx), CAT and superoxide dismutase (SOD) in healthy rats
At the end of the study, interestingly, all the antioxidants GPx, CAT, SOD and the oxidant MDA lipid peroxidation values were decreased in group high dose Spirulina compared to Control (p < 0.05)
Summary
Free radicals are important reactive molecules which designate for oxidative stress imbalance between oxidative and antioxidative status. The oxidant molecules have a role on cellular damage with radical oxygen species, the antioxidant molecules suppress and scavenge free radicals. The most important oxidative molecule known as malondialdehyde (MDA) damages cells or tissues in stressful situations such as diseases, over nutrition or high protein, and thereby oxidative-antioxidative balance reduces. Glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT) and superoxide dismutase (SOD) are the best-known antioxidant markers called as enzymatic antioxidants. These enzymatic molecules are capable of either removing or scavenging free radicals and their actions
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