Abstract
The purpose of the present study is to evaluate the combined effect of electrical stimulation using middle frequency (ES) and eccentric contraction on disuse atrophy in deep portion of calf muscles induced by hindlimb unloading . Rats were randomly divided into the control, hindlimb unloading for 2 weeks (HU), HU plus ES combined concentric (HU+cES), isometric (HU+iES), and eccentric (HU+eES) contraction groups. The animals in the ES groups were stimulated electrically using middle frequency current twice a day during the unloading period. Animals undergoing HU for 2 weeks exhibited the significant loss of muscle mass, decreased cross‐sectional area of muscle fibers, and overexpression of ubiquitinated protein in the soleus muscles compared with the control animals. HU+eES inhibited the HU‐induced loss of muscle mass, decreased cross‐sectional area of muscle fibers in the soleus muscles. In addition, the HU+eES inhibited the overexpression of ubiquitinated protein in the soleus muscles. Furthermore, the HU+eES inhibited the HU‐induced above factors in the soleus muscles compared with ES combined using other types of contraction groups. These results suggested that the combination of electrical stimulation with eccentric contraction might contribute to higher preventive effects on muscle atrophy in the deep portion of calf muscle.Grant Funding Source: Supported by The Japanese Society of Physio Therapeutics
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