Abstract
Materials and Methods Neonatal rats received a single dose of sodium selenite as an intraperitoneal injection (30 μmol/kg) on day 10 postnatal to induce cataract. Animals were then posttreated with various oral solutions of A. officinalis extract at 200 mg/kg or 400 mg/kg once daily on days 10–16 postnatal. Cataract was evaluated by slit-lamp, and lens opacification was analyzed in each group 24 hours after the last treatment at day seven postadministration of the extracts or vehicle. The total protein concentration of lenses, glutathione reductase activity as the glutathione antioxidant capacity, and malondialdehyde content as a marker of lipid peroxidation were further assessed in removed rat lenses on day 30 postnatal. Results All lenses in the healthy and control plant groups were clear. Sodium selenite significantly increased cataract grade (2.8 ± 0.2) when compared to the healthy group (p = 0.001). However, cataract grades were decreased considerably as 1.9 ± 0.72 and 1.5 ± 0.85 in groups that received 200 mg/kg and 400 mg/kg oral extract of A. officinalis, respectively. A. officinalis extract also restored all abnormalities of biochemical markers induced by sodium selenite. Conclusion Our data suggest that A. officinalis could be a promising candidate as a safe alternative treatment in cataracts upon further clinical trials. This effect is probably associated with the antioxidant activity of A. officinalis.
Highlights
Cataract is a disease that the eye lens becomes progressively opaque, resulting in blurred vision, cloudiness, or the opacification of the lens of the human eye [1,2,3]
Since oxidative stress is implicated in cataract formation, the application of antioxidant agents, which may be capable of successfully penetrating the lens tissue, may counteract oxidationrelated cataractogenesis
In (2015) study, we showed that E. amoenum extract significantly had a protective effect on selenite-induced cataract in rat. is effect is probably associated with the antioxidant activity of this medicinal plant, resulted in inhibiting oxidative stress caused by cataract [12]
Summary
Cataract is a disease that the eye lens becomes progressively opaque, resulting in blurred vision, cloudiness, or the opacification of the lens of the human eye [1,2,3]. Is effect is probably associated with the antioxidant activity of this medicinal plant, resulted in inhibiting oxidative stress caused by cataract [12]. In another experiment, we assessed the preventive effects of Origanum vulgare extract, a potent antioxidant herbal medicine, on selenite-induced cataractogenesis. E anticataract effects of O. vulgare extract could be based on the high amount of flavonoids and polyphenolic compounds, resulting in the strengthen endogenous antioxidant enzymes defenses system of the body, inhibition of oxidative stress conditions in cataract, and scavenging free radicals that caused lipid peroxidation by direct or indirect antioxidant mechanisms [13]. Erefore, the effects of the hydroalcoholic extract of Asparagus officinalis L, a traditional antioxidative plant, on cataract formation of sodium selenite were evaluated. Our data suggest that A. officinalis could be a promising candidate as a safe alternative treatment in cataracts upon further clinical trials. is effect is probably associated with the antioxidant activity of A. officinalis
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