Abstract
Background: Oxygen free radicals are known as one of the causes of kidney injury. Therefore, Berberis vulgaris which has high level of antioxidant activity may be able to prevent this injury by elimination of free radicals. Objectives: This study was aimed to investigate the protective effect of B. vulgaris extract on contrast media-induced nephrotoxicity. Materials and Methods: To conduct this experimental study, 30 male rats were randomized to three groups; Control, contrast media, and contrast media + B. vulgaris extract. After the treatment, histopathological damages to the kidney tissues were comparatively studied. Results: Tissue damage was greater in the contrast media-treated group than the other two groups (P < 0.001). In group treated with B. vulgaris extract, the rate of tissue damage deceased significantly (P < 0.001). Conclusions: This study showed the positive effects of B. vulgaris on contrast media-induced nephrotoxicity. This inexpensive and non-toxic medicinal plant might be used as an effective agent for people at risk of contrast-induced acute kidney injury (CI-AKI).
Highlights
Oxygen free radicals are known as one of the causes of kidney injury
This study investigated the protective effect of B. vulgaris on damage to kidney tissue due to intravenous administration with contrast media
Intravenous administration with contrast media caused exacerbation of tissue damage compared to normal saline administration in the healthy group (P < 0.001)
Summary
Oxygen free radicals are known as one of the causes of kidney injury. Berberis vulgaris which has high level of antioxidant activity may be able to prevent this injury by elimination of free radicals. Objectives: This study was aimed to investigate the protective effect of B. vulgaris extract on contrast media-induced nephrotoxicity. Conclusions: This study showed the positive effects of B. vulgaris on contrast media-induced nephrotoxicity. This inexpensive and non-toxic medicinal plant might be used as an effective agent for people at risk of contrast-induced acute kidney injury (CI-AKI). Contrast-induced acute kidney injury (CI-AKI) has been considered as an important factor in induction of acute renal dysfunction [1]. Contrast media-induced acute kidney injury (AKI) is the cause of approximately 10% of the impairments of renal function leading to hospitalization [4]. There are certain risk factors that make it difficult to excrete contrast media from the body, including renal failure, diabetes mellitus, advanced age, and the characteristics and dosage of contrast media.
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