The prevention of infectious endophthalmitis after intraocular foreign body injury in Tibet high altitude district

Abstract

Objective To evaluate the efficacy of early intravitreal Vancomycin injection for prevention of infectious endophthalmitis after intraocular foreign body injury. Methods One hundred and five eyes of 105 cases with intraocular foreign body injury were divided into two groups. Fifty-five cases were recruited in research group, before suturing the eyeball wound, the foreign body was attracted with magnet firstly, then intravitreal Vancomycin(1 mg) injection was performed and the broad spectrum antibiotics was used after the operation. Some cases failed to attract the foreign body were transferred to another hospital for vitrectomy. In control group, a similar treatment except for intravitreal Vancomycin injection was carried out in 50 cases. The incidences of infectious endophthalmitis between the two groups were compared. Results After operation, infectious endophthalmitis occurred in 3 cases(5.45%) in research group (55 cases). infectious endophthalmitis occurred in 9 cases(18.00%) in control group (50 cases). The difference in incidence of infectious endophthalmitis between the two groups was statistically significant (χ2=4.072, P<0.05). Conclusion Early intravitreal Vancomycin injection can reduce the incidence of incidence of infectious endophthalmitis after intraocular foreign body injury. Key words: Foreign body, intraocular; Endophthalmitis; Injection, intravitreal; Vancomycin; Prevention