Abstract
A higher incidence of Rhesus group D (RHD)-negative blood group among patients with Small Cell Cancer of the lung (SCLC) had been previously reported but reproducibility was not confirmed, and clinical relevance is undefined. We tested 1,090 (SCLC; Adenocarcinoma: Squamous = 202:536:352) cases of lung cancer over a 3-year period at a single institution and noted a higher frequency RHD negative status among SCLC cases (19/89) compared with non-SCLC (61/480) that could not be explained by differences in ethnic background in the patient population. While we confirmed poor ECOG functional status, advanced stage, elevated alkaline phosphatase, and low albumin levels as independent and significant factors for reduced overall survival (OS), we did not detect any clinical outcome correlations with RHD status in our dataset. Patients with SCLC rarely undergo surgical resection resulting in limited data for blood group analyses. We have now detected a higher rate of RHD-negative status in patients with SCLC compared with all other subtypes of lung cancer. The clinical and biological basis for this observation is undefined and we feel that this may be explained by variations in ethnic background.
Highlights
Small cell lung cancer (SCLC) is an aggressive neuroendocrine subtype with poor prognosis [1]
We have studied 569 cases of lung cancer including 89 Small Cell Cancer of the lung (SCLC) to test if there is an association between Rhesus group D (RHD) status and overall survival among these patients
RHD–ve SCLC patients accounted for 21.35% of all SCLC (19/89)
Summary
Small cell lung cancer (SCLC) is an aggressive neuroendocrine subtype with poor prognosis [1]. Studies on non-small cell lung cancer subtypes have shown that a relationship between the expression of Rhesus antigens on blood erythrocytes and overall survival may exist among patients having adenocarcinoma of the lung. Such a relationship was not reported with non-adenocarcinoma lung cancers types in that report [3]. Urun et al reported an association between RHD–ve blood group and a higher risk of lung cancer [6] Their analysis did not look at different histological lung-cancer subtypes. We have studied 569 cases of lung cancer including 89 SCLC to test if there is an association between RHD status and overall survival among these patients
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