Abstract
Background Migraine is a severe and debilitating neurologic disorder and is claimed to be the sixth disabling illness in the world. This study aimed to determine the overall prevalence of restless legs syndrome (RLS) in patients with migraine through a systematic review and meta-analysis. Methods To identify and select related studies, the Scopus, ScienceDirect, Embase, SID, IranDoc, Web of Science, Knowledge Network System Medline (PubMed), and Google Scholar databases were searched. All related cross-sectional studies, published in English or Persian language between January 2000 and December 2019 and using the keywords such as migraine, restless leg syndrome, sleep disorder, RLS, and migraine disorder, were collected. The heterogeneity of the studies was assessed using the I2 index, and the data analysis was performed using the Comprehensive Meta-Analysis software. Results Analysis was conducted on the reported results of the final 12 articles with the total sample size of 15196. The overall prevalence of RLS in patients with migraine was 16.3% (95% CI: 12.6–20.8%). The prevalence of RLS migraine patients decreased with increasing the sample size, and the prevalence of RLS migraine patients increased with increasing the research year, which was statistically significant (P < 0.05). Conclusion This study highlights that RLS is high in patients with migraine, and therefore, the clinicians should be aware of its incidence and take preventive measures.
Highlights
Migraine is a severe and debilitating neurologic disorder and is claimed to be the sixth disabling illness in the world. is study aimed to determine the overall prevalence of restless legs syndrome (RLS) in patients with migraine through a systematic review and meta-analysis
All related cross-sectional studies published in English or Persian language, between January 2000 and December 2019, were identified and selected. e keywords used in the search process were migraine, migraineurs, restless legs syndrome, sleep disorder, RLS, and migraine disorder
A total of 2,866 articles were identified, of which 254 articles were obtained from IranDoc, 4 articles from SID, 402 articles from Medline (PubMed), 242 articles from ScienceDirect, 378 articles from Scopus, 526 articles from Embase, 266 articles from Web of Science, and 756 articles were obtained from Google Scholar
Summary
Migraine is a severe and debilitating neurologic disorder and is claimed to be the sixth disabling illness in the world. is study aimed to determine the overall prevalence of restless legs syndrome (RLS) in patients with migraine through a systematic review and meta-analysis. Is study aimed to determine the overall prevalence of restless legs syndrome (RLS) in patients with migraine through a systematic review and meta-analysis. All related cross-sectional studies, published in English or Persian language between January 2000 and December 2019 and using the keywords such as migraine, restless leg syndrome, sleep disorder, RLS, and migraine disorder, were collected. Migraine is a severe and debilitating neurologic disorder which is realised with local throbbing sensation in the head. It is a type of disturbance in the subcortical aminergic sensory modulatory systems [1,2,3]. The causes of the disorder are not well understood, and the triggers of migraine vary from a person to another. Migraine affects the quality of life and results in healthcare costs for the patients [6]
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